MP28-13 ACTIVATION OF INTRAVESICAL MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) RECEPTORS MEDIATES BLADDER PAIN
نویسندگان
چکیده
منابع مشابه
Macrophage Migration Inhibitory Factor Mediates PAR-Induced Bladder Pain
INTRODUCTION Macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine, is constitutively expressed in urothelial cells that also express protease-activated receptors (PAR). Urothelial PAR1 receptors were shown to mediate bladder inflammation. We showed that PAR1 and PAR4 activator, thrombin, also mediates urothelial MIF release. We hypothesized that stimulation of urothelial PA...
متن کاملCorrelation between urine macrophage migration inhibitory factor (MIF)/creatinine ratio and time after kidney transplantation
Abstract Background: Despite the long-standing association of macrophage migration inhibitory factor (MIF) with delayed-type hypersensitivity response, the potential role of MIF in chronic allograft nephropathy is unknown. The association between upregulation of MIF expression, macrophage and T cell infiltration and the severity of chronic allograft nephropathy suggests that MIF may be an ...
متن کاملCurrent developments of macrophage migration inhibitory factor (MIF) inhibitors.
The cytokine macrophage migration inhibitory factor (MIF) is regarded as a major regulator of inflammation and a key mediator that counter-regulates the inhibitory effects of glucocorticoids within the immune system. Therefore, MIF is a therapeutic target for the treatment of inflammatory and autoimmune diseases. In addition, MIF was found to be implicated in cancer pathogenesis. Current therap...
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Background MIF via its receptor, CD74, initiates a signaling cascade that leads to proliferation and survival of cells. Also, MIF binding to CD74 activates p38 signaling pathways that lead to positive effect on the expression of COX-2. The aim of this study was to evaluate the gene expression profile of MIF, CD74 and COX-2 in normal, ectopic and eutopic endometrium during menstrual cycle. The e...
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Authors: 5 Gunnar R. Husebø, Per S. Bakke, Rune Grønseth, Jon A. Hardie, Thor Ueland, Pål 6 Aukrust, Tomas M.L. Eagan. 7 8 Dept. of Thoracic Medicine, Haukeland University Hospital, Bergen Norway 9 2 Dept. of Clinical Science, University of Bergen, Norway 10 Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway 11 K.G. Jebsen Inflammatory Research Centre...
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ژورنال
عنوان ژورنال: Journal of Urology
سال: 2020
ISSN: 0022-5347,1527-3792
DOI: 10.1097/ju.0000000000000867.013